1-Piperazinecarboxylic acid, ethyl ester → 2-Tert-butyl-5-[4-carbethoxypiperazin-1-yl]-6-nitrobenzothiazole

HRID 2118752

反応式

HRID 2118752 の反応式
[C:1]([C:5]1[S:6][C:7]2[CH:13]=[C:12]([N+:14]([O-:16])=[O:15])[C:11](Cl)=[CH:10][C:8]=2[N:9]=1)([CH3:4])([CH3:3])[CH3:2].[C:18]([N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)([O:20][CH2:21][CH3:22])=[O:19]>O>[C:1]([C:5]1[S:6][C:7]2[CH:13]=[C:12]([N+:14]([O-:16])=[O:15])[C:11]([N:26]3[CH2:25][CH2:24][N:23]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:28][CH2:27]3)=[CH:10][C:8]=2[N:9]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 197942022-Tert-butyl-5-chloro-6-nitrobenzothiazole

生成物 1

HCID 201929322-Tert-butyl-5-[4-carbethoxypiperazin-1-yl]-6-nitrobenzothiazole

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 3.5 g of 2-tert.-butyl-5-chloro-6-nitrobenzothiazole, described in Example 5, and 5.8 g of N-carbethoxypiperazine is heated at 180° for 2 hours, cooled and poured into water. The solid is filtered, washed with water and crystallised from isopropyl alcohol to give 2-tert-butyl-5-[4-carbethoxypiperazin-1-yl]-6-nitrobenzothiazole, melting at 100°-102°.

後処理

  1. temperatureis heated at 180° for 2 hours
  2. temperaturecooled
  3. filtrationThe solid is filtered
  4. washwashed with water
  5. customcrystallised from isopropyl alcohol

出典と根拠

ORDレコード
ord-bfa4d8d9fa174f29b8406fa1c70674a3
出典データセット
uspto-grants-1987_07
特許番号
US04680301

関連ノート

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