2-Tert-butyl-5-(4-methylpiperidin-1-yl)-6-nitrobenzothiazole → 6-Amino-2-tert-butyl-5-(4-methylpiperidin-1-yl)benzothiazole

HRID 2118761

反応式

HRID 2118761 の反応式
[C:1]([C:5]1[S:6][C:7]2[CH:13]=[C:12]([N+:14]([O-])=O)[C:11]([N:17]3[CH2:22][CH2:21][CH:20]([CH3:23])[CH2:19][CH2:18]3)=[CH:10][C:8]=2[N:9]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[Ni]>[NH2:14][C:12]1[C:11]([N:17]2[CH2:22][CH2:21][CH:20]([CH3:23])[CH2:19][CH2:18]2)=[CH:10][C:8]2[N:9]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[S:6][C:7]=2[CH:13]=1

参加物

4

反応物 1

HCID 197941892-Tert-butyl-5-(4-methylpiperidin-1-yl)-6-nitrobenzothiazole

生成物 1

HCID 197941866-Amino-2-tert-butyl-5-(4-methylpiperidin-1-yl)benzothiazole

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

A solution of 15.2 g of 2-tert-butyl-5-[4-methylpiperidin-1-yl]-6-nitrobenzothiazole in 600 ml of methanol is hydrogenated in presence of 6.5 g of raney nickel at room temperature. After removing the catalyst the solution is concentrated and the solid filtered to give 6-amino-2-tert-butyl-5-[4-methylpiperidin-1-yl]benzothiazole melting at 146°-148°.

後処理

  1. customAfter removing the catalyst the solution
  2. concentrationis concentrated
  3. filtrationthe solid filtered

出典と根拠

ORDレコード
ord-0c52bcae42524bf7a8e399ce69974129
出典データセット
uspto-grants-1987_07
特許番号
US04680301

関連ノート

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