m-Chloroperbenzoic acid → 1-Acetyl-4-methylsulfinylazetidine-2-one

HRID 2118780ノート

反応式

HRID 2118780 の反応式
[C:1]([N:4]1[CH:7]([S:8][CH3:9])[CH2:6][C:5]1=[O:10])(=[O:3])[CH3:2].ClC1C=CC=C(C(OO)=[O:19])C=1>C(Cl)Cl>[C:1]([N:4]1[CH:7]([S:8]([CH3:9])=[O:19])[CH2:6][C:5]1=[O:10])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 145437851-Acetyl-4-(methylthio)azetidin-2-one

生成物 1

HCID 197488041-Acetyl-4-methylsulfinylazetidine-2-one収率 40%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 130 mg (0.82 mM) N-acetyl-4-methylthioazetidinone and 200 mg (0.93 nM) 80% m-chloroperbenzoic acid in 5 ml methylene chloride was stirred at room temperature 5 minutes. After removing the solvent in vacuo. The residue was chromatographed on 2-2000μ silica gel plates in hexane/ethyl acetate to yield 57 mg (40%) of 1-acetyl-4-methylsulfinylazetidine-2-one.

後処理

  1. customAfter removing the solvent in vacuo
  2. customThe residue was chromatographed on 2-2000μ silica gel plates in hexane/ethyl acetate

出典と根拠

ORDレコード
ord-e588fe9aa1f64afda35fcea1cd348803
出典データセット
uspto-grants-1987_07
特許番号
US04680391

反応ノート

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