Potassium Carbonate → 2-(2-Chloroethoxy)benzene-1-sulfonamide

HRID 2118928

反応式

HRID 2118928 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].C(=O)([O-])[O-].[K+].[K+].C1(C)C=CC(C(S(O[CH2:30][CH2:31][Cl:32])(=O)=O)=O)=CC=1>C(C(C)=O)C>[Cl:32][CH2:31][CH2:30][O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:9])=[O:10]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 6375462-Hydroxybenzene-1-sulfonamideHCID 539698672-Chloroethyl p-toloylsulfonate

生成物 1

HCID 137294542-(2-Chloroethoxy)benzene-1-sulfonamide

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

A mixture of 9.0 g of 2-hydroxyphenylsulfonamide, 7.9 g of potassium carbonate, 13.3 g of 2-chloroethyl p-toloylsulfonate and 80 ml of ethylmethylketone is refluxed for 40 hours. The reaction mixture is cooled to room temperature, filtrated and evaporated to dryness. From the oily residue crystallise after addition of a small portion of methylene chloride 7.0 g of 2-(2-chloroethoxy)-phenylsulfonamide, m.p. 110° C.

後処理

  1. temperatureis refluxed for 40 hours
  2. filtrationfiltrated
  3. customevaporated to dryness
  4. customFrom the oily residue crystallise
  5. additionafter addition of a small portion of methylene chloride 7.0 g of 2-(2-chloroethoxy)-phenylsulfonamide, m.p. 110° C.

出典と根拠

ORDレコード
ord-086e0da574614fe2b03935b0070c2db1
出典データセット
uspto-grants-1987_07
特許番号
US04681619

関連ノート

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