Triethylamine → 5-Et-ddU

HRID 2119040ノート

反応式

HRID 2119040 の反応式
[CH2:1]([C:3]1[C:4](=[O:18])[NH:5][C:6](=[O:17])[N:7]([CH:16]=1)[C@@H:8]1[O:14][C@H:11]([CH2:12][OH:13])[C@@H:10](I)[CH2:9]1)[CH3:2].C(N(CC)CC)C.[H][H]>CO.[Pd]>[CH2:1]([C:3]1[C:4](=[O:18])[NH:5][C:6](=[O:17])[N:7]([CH:16]=1)[C@@H:8]1[O:14][C@H:11]([CH2:12][OH:13])[CH2:10][CH2:9]1)[CH3:2]

参加物

6

反応物 3

HCID 8471TriethylamineHCID 451824Uridine, 2',3'-dideoxy-5-ethyl-3'-iodo-HCID 178418361HCID 178418361、化合物

生成物 1

HCID 4514525-Et-ddU収率 75%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

5-Ethyl-3'-iodo-2',3'-dideoxyuridine (432 mg, 0.87 mmole) is dissolved in methanol (40 ml) and triethylamine (0.5 ml) is added along with 10% Pd/C (200 mg). The mixture is then stirred in an atmosphere of hydrogen at room temperature for 30 min. After filtration of catalyst, the filtrate is evaporated to dryness. Purification of the product was achieved on silica gel plates using chloroform-methanol (20:1) to obtain a solid (150 mg, 75%).

後処理

  1. filtrationAfter filtration of catalyst
  2. customthe filtrate is evaporated to dryness
  3. customPurification of the product

出典と根拠

ORDレコード
ord-4848d14c350f46678b0fe26dcce9dab9
出典データセット
uspto-grants-1987_07
特許番号
US04681933

反応ノート

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