Pivaloyl chloride → 2,4,4'-Tripivaloyloxybenzophenone

HRID 2119170ノート

反応式

HRID 2119170 の反応式
[OH:1][C:2]1[CH:16]=[C:15]([OH:17])[CH:14]=[CH:13][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1)=[O:5].[C:18](Cl)(=[O:23])[C:19]([CH3:22])([CH3:21])[CH3:20]>N1C=CC=CC=1>[C:18]([O:1][C:2]1[CH:16]=[C:15]([O:17][C:18](=[O:23])[C:19]([CH3:22])([CH3:21])[CH3:20])[CH:14]=[CH:13][C:3]=1[C:4]([C:6]1[CH:7]=[CH:8][C:9]([O:12][C:18](=[O:23])[C:19]([CH3:22])([CH3:21])[CH3:20])=[CH:10][CH:11]=1)=[O:5])(=[O:23])[C:19]([CH3:22])([CH3:21])[CH3:20]

参加物

4

反応物 2

HCID 62493Pivaloyl chlorideHCID 738522,4,4'-Trihydroxybenzophenone

生成物 1

HCID 140104022,4,4'-Tripivaloyloxybenzophenone

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A solution of 2.3 g (0.01 mole) of 2,4,4'trihydroxybenzophenone was warmed to 50° C. with 3.65 g (0.035 mole) of pivaloyl chloride in 75 mls of dry pyridine. After 2 hrs. at 5° C., the solvent was evaporated under N2 stream and H2O added to the residue. The oily material was extracted with CH2Cl2 and washed with dilute K2CO3. The organic layer was dried over MgSO4. The glass which was recovered after solvent removal was crystallized from ethanol; 4.20 g (86%) yield; M.P.~94°-96° C.

後処理

  1. customat 5° C., the solvent was evaporated under N2 stream and H2O
  2. additionadded to the residue
  3. extractionThe oily material was extracted with CH2Cl2
  4. washwashed with dilute K2CO3
  5. dry with materialThe organic layer was dried over MgSO4
  6. customThe glass which was recovered
  7. customafter solvent removal
  8. customwas crystallized from ethanol
  9. custom4.20 g (86%) yield

出典と根拠

ORDレコード
ord-6e738dac7e324a4f9001c1f968844b2c
出典データセット
uspto-grants-1987_07
特許番号
US04683241

反応ノート

読み込み中…