Pyridine → N2-isobutyryl-2'-OMe-guanosine
反応式
C([CH:5]([OH:35])[C@H:6]1[O:10][C@@H:9]([N:11]2[C:26]3[C:14]([C:15]([N:17]=[C:18]([N:25]=3)[NH:19][C:20](=[O:24])[CH:21]([CH3:23])[CH3:22])=[O:16])=[N:13][C:12]2=[SiH2])[C@H:8]([O:28][CH3:29])[C@@H:7]1[O:30]C(C)(C)C)(C)(C)C.N1C=CC=CC=1.N1C=CC=CC=1.F>ClCCl>[CH3:29][O:28][C@@H:8]1[C@H:7]([OH:30])[C@@H:6]([CH2:5][OH:35])[O:10][C@H:9]1[N:11]1[C:26]2[N:25]=[C:18]([NH:19][C:20](=[O:24])[CH:21]([CH3:23])[CH3:22])[NH:17][C:15](=[O:16])[C:14]=2[N:13]=[CH:12]1参加物
5
実験手順
To a stirred solution of (66) (0.51 g, 1 mmol) in anhydrous dichloromethane (5 ml) was added pyridine (0.5 ml) followed by hydrogen fluoride—pyridine (38.5 M, 0.1 ml). After 15 min the solvent was removed in vacuo. Flash chromatography using a gradient of 5-10% methanol in dichloromethane afforded (67) as white foam, 0.34 g, 93% yield.