Water → 3-(Azidomethyl)-5-methyl-1,2-oxazole

HRID 2119980ノート

反応式

HRID 2119980 の反応式
Br[CH2:2][C:3]1[CH:7]=[C:6]([CH3:8])[O:5][N:4]=1.[N-:9]=[N+:10]=[N-:11].[Na+].O>CC(C)=O>[N:9]([CH2:2][C:3]1[CH:7]=[C:6]([CH3:8])[O:5][N:4]=1)=[N+:10]=[N-:11]

参加物

5

反応物 3

HCID 962WaterHCID 33557Sodium AzideHCID 27763043-(Bromomethyl)-5-methylisoxazole

生成物 1

HCID 234409373-(Azidomethyl)-5-methyl-1,2-oxazole収率 242.3%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of the 3-bromomethyl-5-methyl-isoxazole (150 mg, 0.9 mmol) in acetone (1 mL) was added NaN3 (166 mg, 0.26 mmol) at rt. The reaction mixture was then stirred for 48 h. Then, the reaction mixture was poured into water (10 mL) and extracted with EtOAc (3×10 mL) dried and evaporated. The product was chromatographed on silica gel eluting with EtOAc/hexane 1:1 to leave the title compound as a colorless liquid (87 mg, 74%). m/z 138.0 (M).

後処理

  1. extractionextracted with EtOAc (3×10 mL)
  2. customdried
  3. customevaporated
  4. customThe product was chromatographed on silica gel eluting with EtOAc/hexane 1:1

出典と根拠

ORDレコード
ord-0654f9e3377149beb4037a60a18fa66d
出典データセット
uspto-grants-2004_02
特許番号
US06686352B2

反応ノート

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