Acetone → 3-Butyl-6-(isopropylamino)-phthalide

HRID 2120183

反応式

HRID 2120183 の反応式
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH2:12][CH2:13][CH2:14][CH3:15])[O:7][C:8]2=[O:9])=[CH:4][CH:3]=1.[CH3:16][C:17]([CH3:19])=O>C(O)C.[Pd]>[CH2:12]([CH:6]1[C:5]2[C:10](=[CH:11][C:2]([NH:1][CH:17]([CH3:19])[CH3:16])=[CH:3][CH:4]=2)[C:8](=[O:9])[O:7]1)[CH2:13][CH2:14][CH3:15]

参加物

5

反応物 2

HCID 180AcetoneHCID 98777066-Amino-3-butyl-phthalide

生成物 1

HCID 99648533-Butyl-6-(isopropylamino)-phthalide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of 4.1 g (20.0 mmol) of compound obtained in Example 4 in 4 ml of acetone and 96 ml of anhydrous ethanol there is added 10% Pd—C catalyst. The mixture is hydrogenated under a hydrogen pressure of 3-3.5 kg/cm2. After the absorption of hydrogen is complete, the catalyst is filtered off and the filtrate is concentrated in vacuo to dryness. The residue is crystallised from dilute ethanol to give the title compound.

後処理

  1. customAfter the absorption of hydrogen
  2. filtrationthe catalyst is filtered off
  3. concentrationthe filtrate is concentrated in vacuo to dryness
  4. customThe residue is crystallised from dilute ethanol

出典と根拠

ORDレコード
ord-8484c0784fa546faa001dddbf1c438e2
出典データセット
uspto-grants-2004_02
特許番号
US06689808B2

関連ノート

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