Nitric Acid → 6-Acetamido-3-butyl-5-nitro-phthalide

HRID 2120189ノート

反応式

HRID 2120189 の反応式
[N+:1]([O-:4])(O)=[O:2].[C:5]([NH:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]([CH2:19][CH2:20][CH2:21][CH3:22])[O:14][C:15]2=[O:16])=[CH:11][CH:10]=1)(=[O:7])[CH3:6]>>[C:5]([NH:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]([CH2:19][CH2:20][CH2:21][CH3:22])[O:14][C:15]2=[O:16])=[CH:11][C:10]=1[N+:1]([O-:4])=[O:2])(=[O:7])[CH3:6]

参加物

3

反応物 2

HCID 944Nitric AcidHCID 232747896-Acetamido-3-butyl-phthalide

生成物 1

HCID 234391106-Acetamido-3-butyl-5-nitro-phthalide

実験手順

To 100 ml of stirred and ice-cold turning nitric acid (sp. gr. 1.50) there are added, in portions, 59 g (0.288 mol) of compound obtained in Example 7 with the temperature below 10° C. The resulting clear solution is put aside at room temperature overnight. The reaction material is poured into crushed ice, and the solid is filtered, washed with water, dried and crystallised from ethanol, giving the title compound.

後処理

  1. additionThe reaction material is poured
  2. custominto crushed ice
  3. filtrationthe solid is filtered
  4. washwashed with water
  5. customdried
  6. customcrystallised from ethanol

出典と根拠

ORDレコード
ord-aae83b5e83bf44a2b51f533fcb26b36a
出典データセット
uspto-grants-2004_02
特許番号
US06689808B2

反応ノート

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