(4-Benzenesulfonyl-1-benzyl-2-hydroxy-7-methyl-octyl)carbamic acid benzyl ester → 2-Amino-5-benzenesulfonyl-8-methyl-1-phenyl-nonan-3-ol

HRID 2120413ノート

反応式

HRID 2120413 の反応式
C(OC(=O)[NH:10][CH:11]([CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[CH:12]([OH:29])[CH2:13][CH:14]([S:20]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)(=[O:22])=[O:21])[CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])C1C=CC=CC=1.[H][H]>C(O)C.[OH-].[OH-].[Pd+2]>[NH2:10][CH:11]([CH:12]([OH:29])[CH2:13][CH:14]([S:20]([C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)(=[O:22])=[O:21])[CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:30][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

参加物

5

反応物 2

HCID 69689188(4-Benzenesulfonyl-1-benzyl-2-hydroxy-7-methyl-octyl)carbamic acid benzyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 696878922-Amino-5-benzenesulfonyl-8-methyl-1-phenyl-nonan-3-ol

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

To a solution of (4-benzenesulfonyl-1-benzyl-2-hydroxy-7-methyl-octyl)-carbamic acid benzyl ester in ethanol is added 10 mole % palladium hydroxide on carbon. The mixture is then shaken on a Parr shaker under 50 psi of hydrogen for approximately 18 h. The catalyst is filtered off and the solution concentrated to give the title compound.

後処理

  1. filtrationThe catalyst is filtered off
  2. concentrationthe solution concentrated

出典と根拠

ORDレコード
ord-8a3374463e6f40f8942fca3a776f1109
出典データセット
uspto-grants-2004_02
特許番号
US06689886B2

反応ノート

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