Hydrochloric Acid → 3-(2-Methyl-pyrimidin-5-yl)-10-(pyrimidin-2-ylamino)-decanoic acid

HRID 2120707ノート

反応式

HRID 2120707 の反応式
C([O:3][C:4](=[O:28])[CH2:5][CH:6]([C:21]1[CH:22]=[N:23][C:24]([CH3:27])=[N:25][CH:26]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]1[N:20]=[CH:19][CH:18]=[CH:17][N:16]=1)C.[OH-].[Na+].Cl>O1CCOCC1>[CH3:27][C:24]1[N:25]=[CH:26][C:21]([CH:6]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]2[N:16]=[CH:17][CH:18]=[CH:19][N:20]=2)[CH2:5][C:4]([OH:28])=[O:3])=[CH:22][N:23]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 206224843-(2-Methyl-pyrimidin-5-yl)-10-(pyrimidin-2-ylamino)-decanoic acid ethyl ester

生成物 1

HCID 234355223-(2-Methyl-pyrimidin-5-yl)-10-(pyrimidin-2-ylamino)-decanoic acid収率 57.1%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A solution of 24-8 (170 mg, 0.441 mmol) in 1,4-dioxane (2 mL) was treated with 1M aqueous NaOH (1.50 mL) at room temperature (90 min). The reaction was neutralized with 1M aqueous HCl (1.50 mL) and the solvents were removed in vacuo. PCTLC (SiO2, 2 mm, 10% MeOH; 25% EtOAc, 65% CHCl3) afforded 24-9 (90 mg).

後処理

  1. customthe solvents were removed in vacuo

出典と根拠

ORDレコード
ord-b69c956a6f6a43edadd8ac83724ac8be
出典データセット
uspto-grants-2004_02
特許番号
US06693101B2

反応ノート

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