Dimethylamine → 4-(4-Dimethylaminosulfonylbenzyl)-nitrobenzene
反応式
[CH3:1][NH:2][CH3:3].ClCCl.Cl[S:8]([C:11]1[CH:26]=[CH:25][C:14]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=2)=[CH:13][CH:12]=1)(=[O:10])=[O:9]>O1CCCC1>[CH3:1][N:2]([CH3:3])[S:8]([C:11]1[CH:12]=[CH:13][C:14]([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([N+:22]([O-:24])=[O:23])=[CH:20][CH:21]=2)=[CH:25][CH:26]=1)(=[O:9])=[O:10]参加物
4
実験手順
A solution of dimethylamine in tetrahydrofuran (2M, excess) was added 4-(4-chlorosulfonylbenzyl)-nitrobenzene dichloromethane hemisolvate (354 mg, 1 mmol) dissolved in tetrahydrofuran (5 mL). The mixture was stirred for 1 hour and extracted with a solution of diethyl ether and dilute potassium carbonate. The organic layer was separated and solvents evaporated. The residue was recrystallized from acetone/hexanes to give 4-(4-dimethylaminosulfonylbenzyl)-nitrobenzene (311 mg, 98%).