Ethanol → HCID 12388282、化合物

HRID 2121091

反応式

HRID 2121091 の反応式
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6]=[CH:7][C:8]([OH:10])=[O:9])=[CH:4][C:3]=1[N+:13]([O-])=O.C(O)C>[Pt]=S.C(OCC)(=O)C>[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([CH2:6][CH2:7][C:8]([OH:10])=[O:9])=[CH:4][C:3]=1[NH2:13]

参加物

5

反応物 2

HCID 702EthanolHCID 6149193-(4-Chloro-3-nitrophenyl)acrylic acid

生成物 1

HCID 12388282HCID 12388282、化合物収率 99.8%

試薬・触媒・溶媒 2

HCID 82861Platinum sulfide (PtS)触媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
50 °C

実験手順

A slurry of 4-chloro-3-nitrocinnamic acid (12.2 g, 53.2 mmol), ethyl alcohol (50 mL) and ethyl acetate (20 mL) was treated with 5% Platinum sulfide on carbon (0.6 g) and was placed in a Parr autoclave. The autoclave was placed under a hydrogen atmosphere and heated overnight at 50° C. After cooling to room temperature, the reaction mixture was filtered through celite, and was concentrated in vacuo to yield 10.6 g of 3-(4-chloro-3-aminophenyl)propionic acid.

後処理

  1. temperatureAfter cooling to room temperature
  2. filtrationthe reaction mixture was filtered through celite
  3. concentrationwas concentrated in vacuo

出典と根拠

ORDレコード
ord-cdfe74b4c4d9483d86cee73568f571cc
出典データセット
uspto-grants-2004_02
特許番号
US06693208B2

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