Nitric Acid → 3-Tert-butyl-2-hydroxy-5-nitrobenzaldehyde
反応式
[C:1]([C:5]1[C:6]([OH:13])=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH:8]=[O:9])([CH3:4])([CH3:3])[CH3:2].[N+:14]([O-])([OH:16])=[O:15]>C(O)(=O)C>[C:1]([C:5]1[C:6]([OH:13])=[C:7]([CH:10]=[C:11]([N+:14]([O-:16])=[O:15])[CH:12]=1)[CH:8]=[O:9])([CH3:4])([CH3:2])[CH3:3]参加物
4
実験手順
5.0 g (28 mmol) of 3-tert-butyl-2-hydroxybenzaldehyde in 8 ml of glacial acetic acid were introduced into a 50 ml two-necked flask fitted with magnetic stirrer and dropping funnel, and 2.8 ml (68 mmol) of nitric acid were added at a temperature of below 5° C. The batch was subsequently stirred further at room temperature for one hour. The product was isolated by precipitation on ice and washed with water. After recyrstallization of the methanol, the product was dried. The yield was 64%.
後処理
- customfitted with magnetic stirrer
- customThe product was isolated by precipitation on ice
- washwashed with water
- dry with materialAfter recyrstallization of the methanol, the product was dried
出典と根拠
- ORDレコード
- ord-190f415a09f143debf5e88e4e9187211
- 出典データセット
- uspto-grants-2004_02
- 特許番号
- US06695977B2
反応ノート
読み込み中…