Bromine → 3-Bromopiperidin-4-one hydrobromide

HRID 2121453ノート

反応式

HRID 2121453 の反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11](=[O:14])[CH2:10][CH2:9]1)=O)CCC.[Br:15]Br>C(Cl)(Cl)Cl>[BrH:15].[Br:15][CH:10]1[C:11](=[O:14])[CH2:12][CH2:13][NH:8][CH2:9]1

参加物

4

反応物 2

HCID 24408BromineHCID 22732029Butyl 4-oxopiperidine-1-carboxylate

生成物 1

HCID 141969683-Bromopiperidin-4-one hydrobromide収率 163.8%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

About 2.6 g of N-butoxycarbonyl-4-piperdone (FIG. 10b) was dissolved in about 70 ml of chloroform; to this solution was added about 2.08 g Br2 over a period of about 30 minutes. The reaction was continued for about 2 hours at room temperature during which a white precipitate of the compound of FIG. 10c was formed. The reaction mixture was filtered and washed with chloroform ether to yield about 2.76 g of the compound of FIG. 10c.

後処理

  1. customa white precipitate of the compound of FIG. 10c was formed
  2. filtrationThe reaction mixture was filtered
  3. washwashed with chloroform ether

出典と根拠

ORDレコード
ord-530324277cb844d0bac02d64ffa9875b
出典データセット
uspto-grants-2004_02
特許番号
US06696455B1

反応ノート

読み込み中…