HCID 69033852、化合物 → 209985-36-4

HRID 2121501ノート

反応式

HRID 2121501 の反応式
C(OC([C:11]1([NH2:32])[N:17]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])[C:15]2[CH:25]=[C:26](Br)[CH:27]=[CH:28][C:14]=2[N:13]([CH3:30])[C:12]1=[O:31])=O)C1C=CC=CC=1>[Pd].CO>[NH2:32][CH:11]1[N:17]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])[C:15]2[CH:25]=[CH:26][CH:27]=[CH:28][C:14]=2[N:13]([CH3:30])[C:12]1=[O:31]

参加物

4

反応物 1

HCID 69033852HCID 69033852、化合物

生成物 1

HCID 14423345209985-36-4

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A flask was charged with 3-(benzyloxycarbonyl)-amino-7-bromo-2,3-dihydro-1-methyl-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one (1 eq.; Example 4-D, Step A) and 10% palladium on carbon. Methanol was added, and the flask was placed under a balloon of H2. The reaction was stirred for 21 hours. The mixture was filtered through celite washing with methanol. The filtrate was concentrated to a white solid.

後処理

  1. filtrationThe mixture was filtered
  2. washthrough celite washing with methanol
  3. concentrationThe filtrate was concentrated to a white solid

出典と根拠

ORDレコード
ord-9e6af2e456b74d9286e8d65cdf9094be
出典データセット
uspto-grants-2004_02
特許番号
US06696438B2

反応ノート

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