Dichloromethane → HCID 135843648、化合物

HRID 2121874ノート

反応式

HRID 2121874 の反応式
C([O:8][C:9]1[CH:17]=[C:16]2[C:12]([CH:13]=[N:14][N:15]2[CH2:18][CH:19]([O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])[CH3:20])=[CH:11][CH:10]=1)C1C=CC=CC=1.ClCCl>CO.[Pd]>[C:25]([Si:22]([CH3:24])([CH3:23])[O:21][CH:19]([CH3:20])[CH2:18][N:15]1[C:16]2[C:12](=[CH:11][CH:10]=[C:9]([OH:8])[CH:17]=2)[CH:13]=[N:14]1)([CH3:27])([CH3:28])[CH3:26]

参加物

5

反応物 2

HCID 6344DichloromethaneHCID 224965766-Benzyloxy-1-[2-(tert-butyldimethyl-silanyloxy)-propyl]-1H-indazole

生成物 1

HCID 135843648HCID 135843648、化合物収率 85%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of the product from Step A (10.6 g, 27 mmol) and palladium-on-carbon (10%, 0.26 g) in methanol (250 mL) was stirred under an atmosphere of hydrogen for 6 h, dichloromethane (100 mL) was added and the mixture filtered. Evaporation of the filtrate gave an off-white solid (7.0 g, 85%): mp 169-174° C.; LC/MS (+APCI) m/z 307 (M+H).

後処理

  1. filtrationthe mixture filtered
  2. customEvaporation of the filtrate

出典と根拠

ORDレコード
ord-d91c7f6372ec47ceb92f87d3cab1dc69
出典データセット
uspto-grants-2004_02
特許番号
US06696476B2

反応ノート

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