m-Nitroacetophenone → 2-Chloro-1-(3-nitrophenyl)ethanone
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:10](=[O:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].S(Cl)([Cl:16])(=O)=O>C(OC(C)C)(C)C>[Cl:16][CH2:11][C:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)=[O:12]参加物
4
実験手順
3′-Nitroacetophenone (2.00 g) was dissolved in diisopropyl ether (12.1 ml) and sulfuryl chloride (6.70 g) was added all at once thereto at 22° C. and refluxed for 6.5 hours. The reaction mixture was allowed to cool to room temperature while stirring, and the precipitated solids were filtered and washed with diisopropyl ether. Drying under reduced pressure yielded the desired 2-chloro-3′-nitroacetophenone (2.01 g; 83.1%).
後処理
- temperaturerefluxed for 6.5 hours
- filtrationthe precipitated solids were filtered
- washwashed with diisopropyl ether
- customDrying under reduced pressure
出典と根拠
- ORDレコード
- ord-51086aa603e145a4ab2999cf686bed9a
- 出典データセット
- uspto-grants-2004_02
- 特許番号
- US06696573B1
反応ノート
読み込み中…