m-Nitroacetophenone → 2-Chloro-1-(3-nitrophenyl)ethanone

HRID 2122056

反応式

HRID 2122056 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:10](=[O:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].S(Cl)([Cl:16])(=O)=O>C(OC(C)C)(C)C>[Cl:16][CH2:11][C:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)=[O:12]

参加物

4

反応物 2

HCID 8494m-NitroacetophenoneHCID 24648Sulfuryl chloride

生成物 1

HCID 74372-Chloro-1-(3-nitrophenyl)ethanone収率 83.2%

試薬・触媒・溶媒 1

HCID 7914Diisopropyl Ether溶媒

実験手順

3′-Nitroacetophenone (2.00 g) was dissolved in diisopropyl ether (12.1 ml) and sulfuryl chloride (6.70 g) was added all at once thereto at 22° C. and refluxed for 6.5 hours. The reaction mixture was allowed to cool to room temperature while stirring, and the precipitated solids were filtered and washed with diisopropyl ether. Drying under reduced pressure yielded the desired 2-chloro-3′-nitroacetophenone (2.01 g; 83.1%).

後処理

  1. temperaturerefluxed for 6.5 hours
  2. filtrationthe precipitated solids were filtered
  3. washwashed with diisopropyl ether
  4. customDrying under reduced pressure

出典と根拠

ORDレコード
ord-51086aa603e145a4ab2999cf686bed9a
出典データセット
uspto-grants-2004_02
特許番号
US06696573B1

関連ノート

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