Trifluoroacetic acid → HCID 68489198、化合物
反応式
O[CH:2]1[C:10]2[C:5](=[C:6]([I:13])[CH:7]=[C:8]([Cl:12])[C:9]=2[Cl:11])[C:4](=[O:14])[N:3]1C(C)(C1C=CC=CC=1)C.FC(F)(F)C(O)=O.C([SiH](CC)CC)C>[N+](C)([O-])=O>[Cl:11][C:9]1[C:8]([Cl:12])=[CH:7][C:6]([I:13])=[C:5]2[C:10]=1[CH2:2][NH:3][C:4]2=[O:14]参加物
5
実験手順
In a similar manner to Step 4 of Example 16, 3-hydroxy-4,5-dichloro-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (347 mg, 0.750 mmol) was dissolved in nitromethane (14 mL), and the solution was treated with trifluoroacetic acid (0.867 mL, 11.3 mmol) and triethylsilane (0.240 mL, 1.50 mmol), followed by purification by slurry using chloroform to obtain 4,5-dichloro-7-iodoisoindolinone (182 mg, yield 74%).
後処理
- customfollowed by purification by slurry
出典と根拠
- ORDレコード
- ord-62cbf3f81bc14809818a48d4201ca5b2
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745641B2
反応ノート
読み込み中…