Trifluoroacetic acid → HCID 68488661、化合物
反応式
O[CH:2]1[C:10]2[C:5](=[C:6]([I:13])[CH:7]=[C:8]([F:12])[C:9]=2[Cl:11])[C:4](=[O:14])[N:3]1C(C)(C1C=CC=CC=1)C.FC(F)(F)C(O)=O.C([SiH](CC)CC)C>[N+](C)([O-])=O>[Cl:11][C:9]1[C:8]([F:12])=[CH:7][C:6]([I:13])=[C:5]2[C:10]=1[CH2:2][NH:3][C:4]2=[O:14]参加物
5
実験手順
In a similar manner to Step 4 of Example 16, 3-hydroxy-4-chloro-5-fluoro-7-iodo-2(1-methyl-1-phenylethyl)isoindolinone (806 mg, 1.81 mmol) was dissolved in nitromethane (32 mL), and the solution was treated with trifluoroacetic acid (1.40 mL, 18.1 mmol) and triethylsilane (0.578 mL, 3.62 mmol), followed by purification by slurry using diisopropylether to obtain 4-chloro-5-fluoro-7-iodoisoindolinone (477 mg, yield 85%).
後処理
- customfollowed by purification by slurry
出典と根拠
- ORDレコード
- ord-5350404a6fff4ba0bf9473457275ea77
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745641B2
反応ノート
読み込み中…