Dimethylformamide → HCID 68492108、化合物

反応式

[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([CH:20]=[CH:21][C:22]=1[CH:23]([O:26][CH3:27])[O:24][CH3:25])[C:8]([NH:10][C:11]([CH3:19])([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH3:12])=[O:9].CN(CCN(C)C)C.CN([CH:39]=[O:40])C>C1COCC1>[CH3:1][O:2][CH2:3][O:4][C:5]1[C:22]([CH:23]([O:26][CH3:27])[O:24][CH3:25])=[CH:21][CH:20]=[C:7]2[C:6]=1[CH:39]([OH:40])[N:10]([C:11]([CH3:19])([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH3:12])[C:8]2=[O:9]

参加物

実験手順

In a similar manner to Step 2 of Example 16, 3-methoxymethoxy-4-dimethoxymethyl-N-(1-methyl-1-phenylethyl)benzamide (3.61 g, 9.67 mmol) was dissolved in THF (100 mL), and the solution was treated with TMEDA (4.70 mL, 31.0 mmol), sec-butyl lithium-hexane solution (1.03 mol/L, 30.0 mL, 30.9 mmol) and DMF (1.65 mL, 21.3 mmol), followed by purification by slurry using chloroform and hexane to obtain 4-methoxymethoxy-5-dimethoxymethyl-3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone (2.95 g, yield 85%).