Trifluoroacetic acid → 4-Hydroxy-5-methoxy-7-iodoisoindolinone
反応式
COC[O:4][C:5]1[C:13]([O:14][CH3:15])=[CH:12][C:11]([I:16])=[C:10]2[C:6]=1[CH:7](O)[N:8](C(C)(C1C=CC=CC=1)C)[C:9]2=[O:17].FC(F)(F)C(O)=O.C([SiH](CC)CC)C>[N+](C)([O-])=O>[OH:4][C:5]1[C:13]([O:14][CH3:15])=[CH:12][C:11]([I:16])=[C:10]2[C:6]=1[CH2:7][NH:8][C:9]2=[O:17]参加物
5
実験手順
In a similar manner to Step 4 of Example 16, 4-methoxymethoxy-5-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (763 mg, 1.58 mmol) was dissolved in nitromethane (12 mL), and the solution was treated with trifluoroacetic acid (1.22 mL, 15.8 mmol) and triethylsilane (2.55 mL, 15.8 mmol), followed by purification by slurry using chloroform to obtain 4-hydroxy-5-methoxy-7-iodoisoindolinone (341 mg, yield 71%).
後処理
- customfollowed by purification by slurry
出典と根拠
- ORDレコード
- ord-dca9ec98d00040359a79974573c43175
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745641B2
反応ノート
読み込み中…