Tetrahydrofuran → (2S,5R)-3,6-dimethoxy-2-(propan-2-yl)-5-[(2,4,5-trifluorophenyl)methyl]-2,5-dihydropyrazine

反応式

[CH3:1][O:2][C:3]1=[N:8][CH2:7][C:6]([O:9][CH3:10])=[N:5][CH:4]1[CH:11]([CH3:12])[CH3:13].[F:19][c:20]1[c:21]([CH2:22][Br:23])[cH:24][c:25]([F:29])[c:26]([F:28])[cH:27]1.[Li:14][CH2:15][CH2:16][CH2:17][CH3:18].[O:30]1[CH2:31][CH2:32][CH2:33][CH2:34]1>>[CH3:1][O:2][C:3]1=[N:8][CH:7]([CH2:22][c:21]2[c:20]([F:19])[cH:27][c:26]([F:28])[c:25]([F:29])[cH:24]2)[C:6]([O:9][CH3:10])=[N:5][CH:4]1[CH:11]([CH3:12])[CH3:13]