Trifluoroacetic acid → 4-Bromo-1,2-dihydro-pyrrolo[3,4-c]pyridin-3-one

HRID 21339ノート

反応式

HRID 21339 の反応式
[Br:1][C:2]1[C:7]2[C:8](=[O:21])[N:9](C(C)(C3C=CC=CC=3)C)[CH:10](O)[C:6]=2[CH:5]=[CH:4][N:3]=1.FC(F)(F)C(O)=O.C([SiH](CC)CC)C>[N+](C)([O-])=O>[Br:1][C:2]1[C:7]2[C:8](=[O:21])[NH:9][CH2:10][C:6]=2[CH:5]=[CH:4][N:3]=1

参加物

5

反応物 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 86628337HCID 86628337、化合物

生成物 1

HCID 768481334-Bromo-1,2-dihydro-pyrrolo[3,4-c]pyridin-3-one収率 34%

試薬・触媒・溶媒 1

HCID 6375Nitromethane溶媒

実験手順

In a similar manner to Step 4 of Example 16, 4-bromo-1-hydroxy-2-(1-methyl-1-phenylethyl)-1,2-dihydropyrrolo[3,4-c]pyridine-3-one (239 mg, 0.688 mmol) was dissolved in nitromethane (12 mL), and the solution was treated with trifluoroacetic acid (1.17 mL, 15.1 mmol) and triethylsilane (0.440 mL, 2.75 mmol), followed by purification by preparative thin-layer chromatography (chloroform/methanol=15/1) to obtain 4-bromo-1,2-dihydropyrrolo[3,4-c]pyridine-3-one (49.1 mg, yield 34%).

後処理

  1. customfollowed by purification by preparative thin-layer chromatography (chloroform/methanol=15/1)

出典と根拠

ORDレコード
ord-1c154c18124c483081af4cb314070f73
出典データセット
uspto-grants-2010_06
特許番号
US07745641B2

反応ノート

読み込み中…