Trifluoroacetic acid → 4,7-Dichloro-1,2-dihydropyrrolo[3,4-c]pyridine-3-one

HRID 21342ノート

反応式

HRID 21342 の反応式
[Cl:1][C:2]1[C:7]2[C:8](=[O:21])[N:9](C(C)(C3C=CC=CC=3)C)[CH:10](O)[C:6]=2[C:5]([Cl:22])=[CH:4][N:3]=1.FC(F)(F)C(O)=O.C([SiH](CC)CC)C.CCCCCC.C(OCC)(=O)C>[N+](C)([O-])=O>[Cl:1][C:2]1[C:7]2[C:8](=[O:21])[NH:9][CH2:10][C:6]=2[C:5]([Cl:22])=[CH:4][N:3]=1

参加物

6

反応物 4

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 21226206Ethyl acetate hexaneHCID 866283394,7-Dichloro-1-hydroxy-2-(1-methyl-1-phenylethyl)-1,2-dihydropyrrolo[3,4-c]pyridine-3-one

生成物 1

HCID 768481314,7-Dichloro-1,2-dihydropyrrolo[3,4-c]pyridine-3-one収率 72%

試薬・触媒・溶媒 1

HCID 6375Nitromethane溶媒

実験手順

in a similar manner to Step 4 of Example 16, 4,7-dichloro-1-hydroxy-2-(1-methyl-1-phenylethyl)-1,2-dihydropyrrolo[3,4-c]pyridine-3-one (38.8 mg, 0.115 mmol) was dissolved in nitromethane (1.6 mL), and the solution was treated with trifluoroacetic acid (0.177 mL, 2.30 mmol) and triethylsilane (55.1 mL, 0.345 mmol), followed by purification by slurry using chloroform/methanol and by preparative thin-layer chromatography (hexane/ethyl acetate=1/1) to obtain 4,7-dichloro-1,2-dihydropyrrolo[3,4-c]pyridine-3-one (16.8 mg, yield 72%).

後処理

  1. customfollowed by purification by slurry

出典と根拠

ORDレコード
ord-a6f2ceabf1f34466a72d6dc411d700eb
出典データセット
uspto-grants-2010_06
特許番号
US07745641B2

反応ノート

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