Trifluoroacetic acid → 4-Chloro-6-methyl-1,2-dihydropyrrolo[3,4-c]pyridine-3-one
反応式
[Cl:1][C:2]1[C:7]2[C:8](=[O:21])[N:9](C(C)(C3C=CC=CC=3)C)[CH:10](O)[C:6]=2[CH:5]=[C:4]([CH3:22])[N:3]=1.FC(F)(F)C(O)=O.C([SiH](CC)CC)C>[N+](C)([O-])=O>[Cl:1][C:2]1[C:7]2[C:8](=[O:21])[NH:9][CH2:10][C:6]=2[CH:5]=[C:4]([CH3:22])[N:3]=1参加物
5
実験手順
In a similar manner to Step 4 of Example 16, 4-chloro-1-hydroxy-6-methyl-2-(1-methyl-1-phenylethyl)-1,2-dihydropyrrolo[3,4-c]pyridine-3-one (70.0 mg, 0.220 mmol) was dissolved in nitromethane (3.5 mL), and the solution was treated with trifluoroacetic acid (0.509 mL, 6.60 mmol) and triethylsilane (0.141 mL, 0.880 mmol), followed by purification by slurry using isopropylether/hexane to obtain 4-chloro-6-methyl-1,2-dihydropyrrolo[3,4-c]pyridine-3-one (25.5 mg, yield 63%).
後処理
- customfollowed by purification by slurry
出典と根拠
- ORDレコード
- ord-c6d8e56438df48b69797ef94b9c3998f
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745641B2
反応ノート
読み込み中…