Hydrogen Bromide → 3-Fluoro-4-hydroxybenzoic acid

HRID 21352

反応式

HRID 21352 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11]C)[C:5]([OH:7])=[O:6].Br>C(O)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[OH:11])[C:5]([OH:7])=[O:6]

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 27334013-Fluoro-4-methoxybenzoic acid

生成物 1

HCID 1604563-Fluoro-4-hydroxybenzoic acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Next, the 3-fluoro-4-methoxybenzoic acid (IV) was digested with HBr (20 ml) and glacial acetic acid (40 ml) overnight. Most of the acetic acid was distilled off and the remaining mixture was diluted with water. The precipitated benzoic acid was extracted in ether; the ether layer was dried, filtered and rotary evaporated to produce 11.0 g of the 3-fluoro-4-hydroxybenzoic acid (V).

後処理

  1. distillationMost of the acetic acid was distilled off
  2. additionthe remaining mixture was diluted with water
  3. extractionThe precipitated benzoic acid was extracted in ether
  4. dry with materialthe ether layer was dried
  5. filtrationfiltered
  6. customrotary evaporated

出典と根拠

ORDレコード
ord-8e57d185e0ee46b387690b2c6fd8b245
出典データセット
uspto-grants-1995_06
特許番号
US05422037

関連ノート

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