Butyl isocyanate → 2-(3-n-Butylureido)-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene
反応式
[NH2:1][C:2]1[S:6][C:5]2[CH2:7][CH2:8][CH2:9][CH2:10][C:4]=2[C:3]=1[C:11]#[N:12].C(N(CC)CC)C.[CH2:20]([N:24]=[C:25]=[O:26])[CH2:21][CH2:22][CH3:23]>C1(C)C=CC=CC=1>[CH2:20]([NH:24][C:25](=[O:26])[NH:1][C:2]1[S:6][C:5]2[CH2:7][CH2:8][CH2:9][CH2:10][C:4]=2[C:3]=1[C:11]#[N:12])[CH2:21][CH2:22][CH3:23]参加物
5
反応条件
- 温度
- 80 °C
実験手順
A mixture of 5.35 g (30 mmol) of 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene (prepared according to Intermediate 1e), 2.0 ml (45 mmol) of triethylamine, 10 ml (90 mmol) of n-butyl isocyanate and 100 ml of toluene was stirred for 16 hours at 80° C. The solid formed was then isolated and was recrystallized from ethanol. Yield: 18%; mp.: 170°-171° C.
後処理
- customThe solid formed
- customwas then isolated
- customwas recrystallized from ethanol
出典と根拠
- ORDレコード
- ord-ea64a0b4663547b6a3e35eaa7469e9c7
- 出典データセット
- uspto-grants-1995_06
- 特許番号
- US05422335
反応ノート
読み込み中…