Dichloromethane → 3-(2-Thienyl)-propanoic acid chloride
反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]([OH:10])=O.C(Cl)[Cl:12]>C(Cl)(=O)C(Cl)=O.CN(C)C=O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]([Cl:12])=[O:10]参加物
5
実験手順
To a solution of 5.0 g (0.032 mol) of 3-(2-thienyl)propionic acid in 2 ml of methylene chloride and 25 ml of oxalyl chloride was added three drops of N,N-dimethylformamide slowly. Following evolution of the gas the reaction mixture was concentrated under vacuum and 20 ml of hexane was added to the residue. The resulting mixture was filtered and the filtrate was concentrated under vacuum. The resulting compound, 3-(2-thienyl)propionyl chloride, was used directly in the following reaction.
後処理
- concentrationwas concentrated under vacuum and 20 ml of hexane
- additionwas added to the residue
- filtrationThe resulting mixture was filtered
- concentrationthe filtrate was concentrated under vacuum
- customThe resulting compound, 3-(2-thienyl)propionyl chloride, was used directly in the following reaction
出典と根拠
- ORDレコード
- ord-ffccd1a407724a43aa8542a5d7381c8b
- 出典データセット
- uspto-grants-1995_06
- 特許番号
- US05422356
反応ノート
読み込み中…