Dichloromethane → 3-(2-Thienyl)-propanoic acid chloride

HRID 21381

反応式

HRID 21381 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]([OH:10])=O.C(Cl)[Cl:12]>C(Cl)(=O)C(Cl)=O.CN(C)C=O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]([Cl:12])=[O:10]

参加物

5

反応物 2

HCID 6344DichloromethaneHCID 7031693-(2-Thienyl)propanoic acid

生成物 1

HCID 149601613-(2-Thienyl)-propanoic acid chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 65578Oxalyl chloride溶媒

実験手順

To a solution of 5.0 g (0.032 mol) of 3-(2-thienyl)propionic acid in 2 ml of methylene chloride and 25 ml of oxalyl chloride was added three drops of N,N-dimethylformamide slowly. Following evolution of the gas the reaction mixture was concentrated under vacuum and 20 ml of hexane was added to the residue. The resulting mixture was filtered and the filtrate was concentrated under vacuum. The resulting compound, 3-(2-thienyl)propionyl chloride, was used directly in the following reaction.

後処理

  1. concentrationwas concentrated under vacuum and 20 ml of hexane
  2. additionwas added to the residue
  3. filtrationThe resulting mixture was filtered
  4. concentrationthe filtrate was concentrated under vacuum
  5. customThe resulting compound, 3-(2-thienyl)propionyl chloride, was used directly in the following reaction

出典と根拠

ORDレコード
ord-ffccd1a407724a43aa8542a5d7381c8b
出典データセット
uspto-grants-1995_06
特許番号
US05422356

関連ノート

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