Sodium Hydroxide → N-(3-Hydroxy-4-methoxybenzenesulphonyl)-1,2-dihydroindole

HRID 2141

反応式

HRID 2141 の反応式
CS([O:5][C:6]1[CH:7]=[C:8]([S:14]([N:17]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19][CH2:18]2)(=[O:16])=[O:15])[CH:9]=[CH:10][C:11]=1[O:12][CH3:13])(=O)=O.[OH-].[Na+]>>[OH:5][C:6]1[CH:7]=[C:8]([S:14]([N:17]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19][CH2:18]2)(=[O:16])=[O:15])[CH:9]=[CH:10][C:11]=1[O:12][CH3:13]

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 19689647N-(3-methanesulphonyloxy-4-methoxybenzenesulphonyl)-1,2-dihydroindole

生成物 1

HCID 19689638N-(3-Hydroxy-4-methoxybenzenesulphonyl)-1,2-dihydroindole収率 100.5%

実験手順

A solution of N-(3-methanesulphonyloxy-4-methoxybenzenesulphonyl)-1,2-dihydroindole (1 g) and saturated aqueous sodium hydroxide solution (2 ml) was heated at 85°-90° C. for 2 hours. The solvent was removed in vacuo and the residue partitioned between ethyl acetate (5 ml) and water (10 ml). The aqueous phase was acidified with 2N HCl and extracted with ethyl acetate (2×10 ml). The combined organic phases were dried over magnesium sulphate and concentrated in vacuo to yield a clear oil. Purification by column chromatography eluting with dichloromethane afforded the desired product as a white solid (0.8 g).

後処理

  1. customThe solvent was removed in vacuo
  2. customthe residue partitioned between ethyl acetate (5 ml) and water (10 ml)
  3. extractionextracted with ethyl acetate (2×10 ml)
  4. dry with materialThe combined organic phases were dried over magnesium sulphate
  5. concentrationconcentrated in vacuo
  6. customto yield a clear oil
  7. customPurification by column chromatography
  8. washeluting with dichloromethane

出典と根拠

ORDレコード
ord-ff57e297cfdc46e5b5870e456c42198a
出典データセット
uspto-grants-1998_03
特許番号
US05728712

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