Hydrochloric Acid → 1-(2-Chloropyridin-4-yl)ethan-1-one

HRID 2151

反応式

HRID 2151 の反応式
[Cl:1][C:2]1[CH:7]=C(C#N)[CH:5]=[CH:4][N:3]=1.[CH3:10][Mg]Cl.Cl.C([O:16][CH2:17][CH3:18])C>>[C:17]([C:18]1[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[CH:7]=1)(=[O:16])[CH3:10]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 5686382-Chloro-4-cyanopyridineHCID 178418332HCID 178418332、化合物

生成物 1

HCID 131452551-(2-Chloropyridin-4-yl)ethan-1-one

実験手順

24.61 g (177.62 mmol) of 2-chloro-4-cyano-pyridine are placed in 1.25 litres of diethyl ether under nitrogen, and 120 ml (22% in tetrahydrofuran, 353 mmol) of methyl-magnesium chloride are added. The red suspension is stirred for 40 h at RT, poured onto 1.25 litres of ice/water and 250 ml of 6N HCl and stirred for 14 h at RT. Extraction with diethyl ether and methylene chloride, drying with MgSO4 and concentration give 4-acetyl-2-chloro-pyridine; Rf =0.5 (methylene chloride:methanol=9:1).

後処理

  1. stirringstirred for 14 h at RT
  2. extractionExtraction with diethyl ether and methylene chloride
  3. dry with materialdrying with MgSO4 and concentration

出典と根拠

ORDレコード
ord-160c9a75cc8c48d189fa78e2f7af0bda
出典データセット
uspto-grants-1998_03
特許番号
US05728708

関連ノート

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