1,2-Dimethoxyethane → 4-(((5'-chloro-2'-fluoro-[2,4'-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile

反応式

[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]([NH:8][CH2:9][C:10]2([C:16]#[N:17])[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)[n:7]1.[CH3:29][O:30][CH2:31][CH2:32][O:33][CH3:34].[Cl:18][c:19]1[c:20]([B:26]([OH:27])[OH:28])[cH:21][c:22]([F:25])[n:23][cH:24]1>>[c:2]1(-[c:20]2[c:19]([Cl:18])[cH:24][n:23][c:22]([F:25])[cH:21]2)[cH:3][cH:4][cH:5][c:6]([NH:8][CH2:9][C:10]2([C:16]#[N:17])[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)[n:7]1

参加物

反応物 3

HCID 80711,2-Dimethoxyethane

HCID 44754822(5-Chloro-2-fluoropyridin-4-yl)boronic acid

HCID 581272764-((6-bromopyridin-2-yl-amino)methyl)tetrahydro-2H-pyran-4-carbonitrile

生成物 1

HCID 581271824-(((5'-chloro-2'-fluoro-[2,4'-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile

出典と根拠

ORDレコード: ord-c789d807b6b2434a92cf419ee69ffb01
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…