3-Methylpyrido(3,4-b)pyrazin-2(1H)-one → HCID 53669727、化合物

HRID 21527ノート

反応式

HRID 21527 の反応式
[CH3:1][C:2]1[C:3](=[O:12])[NH:4][C:5]2[C:10]([N:11]=1)=[CH:9][N:8]=[CH:7][CH:6]=2.[H][H]>CO.[Pd].[Pd].[C]>[CH3:1][CH:2]1[NH:11][C:10]2[C:5](=[CH:6][CH:7]=[N:8][CH:9]=2)[NH:4][C:3]1=[O:12]

参加物

6

反応物 2

HCID 217791363-Methylpyrido(3,4-b)pyrazin-2(1H)-oneHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 53669727HCID 53669727、化合物収率 82%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

3-Methyl-1,4,6-triazanaphthalen-2(1H)-one (J. W. Clark-Lewis, R. P. Singh J. Chem. Soc. 1962, 3162) (3.1 g, 0.02 mol) was hydrogenated in 300 ml of methanol with palladium catalysis (10% Pd/carbon) under 1 atm of hydrogen. After hydrogen uptake ceased, the catalyst was filtered off with suction, the solvent was removed, and the residue was stirred with diethyl ether and filtered off with suction. 2.6 g (82%) of the desired product of melting point 230° C. (dec.) were obtained.

後処理

  1. filtrationthe catalyst was filtered off with suction
  2. customthe solvent was removed
  3. filtrationfiltered off with suction

出典と根拠

ORDレコード
ord-b566065b42fe4b3faa3ce20642721aa8
出典データセット
uspto-grants-1995_06
特許番号
US05424311

反応ノート

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