Hydrochloric Acid → 2-Acetyl-4-methoxyphenyl 4-nitrobenzoate

HRID 215675

反応式

HRID 215675 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([OH:12])=[C:7]([C:9](=[O:11])[CH3:10])[CH:8]=1.[N+:13]([C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[CH:18][CH:17]=1)([O-:15])=[O:14].Cl>N1C=CC=CC=1>[C:9]([C:7]1[CH:8]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=1[O:12][C:20](=[O:21])[C:19]1[CH:18]=[CH:17][C:16]([N+:13]([O-:15])=[O:14])=[CH:24][CH:23]=1)(=[O:11])[CH3:10]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 85024-Nitrobenzoyl chlorideHCID 697141-(2-Hydroxy-5-methoxyphenyl)ethan-1-one

生成物 1

HCID 7760892-Acetyl-4-methoxyphenyl 4-nitrobenzoate

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

5′-methoxy-2′-hydroxyacetophenone (1.5 g, 9.03 mmol) was added to a pyridine solution (20 ml) that contained 4-nitrobenzoyl chloride (1.72 g, 9.26 mmol) in an ice bath. The obtained mixture was reacted at room temperature for 30 minutes, and the reaction solution was then poured into 1 N hydrochloric acid under cooling on ice. The obtained mixture was intensively stirred. The obtained precipitate was collected by filtration, and the filtrate was then washed with purified water, so as to obtain a product of interest, 4-nitrobenzoic acid 2-acetyl-4-methoxyphenyl ester (compound 21). Yield: 2.49 g (yield constant: 87.4%)

後処理

  1. customThe obtained mixture was reacted at room temperature for 30 minutes
  2. temperatureunder cooling on ice
  3. filtrationThe obtained precipitate was collected by filtration
  4. washthe filtrate was then washed with purified water

出典と根拠

ORDレコード
ord-0fda36c95d0a4a968ebfdb678629eeee
出典データセット
uspto-grants-2012_06
特許番号
US08192717B2

関連ノート

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