Trimethylsilyl iodide → HCID 178468932、化合物

反応式

[CH2:1]([O:3][C:4](=[O:20])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:13]=[N:14][C:15]([O:18]C)=[CH:16][CH:17]=2)[CH:6]=1)[CH3:2].I[Si](C)(C)C>C(#N)C.O>[CH2:1]([O:3][C:4](=[O:20])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:13]=[N:14][C:15]([OH:18])=[CH:16][CH:17]=2)[CH:6]=1)[CH3:2]

参加物

実験手順

A solution of 3-(6-methoxy-pyridin-3-yloxy)-benzoic acid ethyl ester (0.5 g, 1.83 mmol) in acetonitrile (8 ml) and iodotrimethylsilane (0.439 g, 2.2 mmol) was refluxed for 1 h, the mixture was diluted with water (8 ml) and extracted with chloroform. The extract was washed with 10% of aqueous Na2S2O3, water, dried over anhydrous Na2SO4 and the solvent was removed under reduced pressure to afford 0.327 g (69%) of 3-(6-hydroxy-pyridin-3-yloxy)-benzoic acid ethyl ester as colorless powder.