Dimethylformamide → 5-Bromo-pyridine-2-carbonyl chloride

HRID 215961ノート

反応式

HRID 215961 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.C(Cl)(=O)C([Cl:14])=O.CN(C)C=O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([Cl:14])=[O:10])=[N:6][CH:7]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 6085445-Bromopyridine-2-carboxylic acid

生成物 1

HCID 190907715-Bromo-pyridine-2-carbonyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a mixture of 5-bromopyridine-2-carboxylic acid (2.5 g, 12 mmol) in methylene chloride (10.0 mL) was added oxalyl chloride (1.6 mL, 18 mmol), followed by N,N-dimethylformamide (0.020 mL, 0.26 mmol). After stirred at RT for 2 h, the mixture was evaporated under reduced pressure. The residue was the acid chloride which was used directly in next step reaction.

後処理

  1. customthe mixture was evaporated under reduced pressure
  2. customwas used directly in next step reaction

出典と根拠

ORDレコード
ord-44363defda564c4996b698d619dbe1e3
出典データセット
uspto-grants-2012_06
特許番号
US08193207B2

反応ノート

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