Sodium borohydride → HCID 59176789、化合物

HRID 215967ノート

反応式

HRID 215967 の反応式
[BH4-].[Na+].[C:3]1([CH:13]=[C:14]2[N:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]3=[N:16][C:15]2=[O:23])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1>C(O)C.CO>[C:3]1([CH2:13][CH:14]2[N:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]3=[N:16][C:15]2=[O:23])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 686995473-[1-Naphthalen-1-yl-methylidene]-imidazo[1,2-a]pyridin-2-one

生成物 1

HCID 59176789HCID 59176789、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 887Methanol溶媒

反応条件

温度
-78 °C

実験手順

To a suspension of 137 mg (3.7 mmol) of sodium borohydride in 15 mL of ethanol is added a solution of 500 mg (1.8 mmol) of 3-[1-naphthalen-1-yl-methylidene]-imidazo[1,2-a]pyridin-2-one in 50 mL of methanol, dropwise at −78° C. After stirring for 10 min at −78° C., the reaction mixture is quenched with saturated aqueous ammonium chloride solution at −78° C. The product is extracted with dichloromethane. The organic layer is dried over magnesium sulfate, filtered and concentrated in vacuo to give the desired compound.

後処理

  1. customdropwise at −78° C
  2. customthe reaction mixture is quenched with saturated aqueous ammonium chloride solution at −78° C
  3. extractionThe product is extracted with dichloromethane
  4. dry with materialThe organic layer is dried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-22fb3b9ad2bc48f99a18ffab9dce5bc0
出典データセット
uspto-grants-2012_06
特許番号
US08193214B2

反応ノート

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