Tetrahydrofuran → N-[(10-Chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quinolizine-1-yl)methyl]-N-(cyanomethyl)formamide

反応式

[C:28]([O:29][CH:31]=[O:32])(=[O:30])[CH3:33].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:27]1)-[c:7]1[c:8]([CH2:22][NH:23][CH2:24][C:25]#[N:26])[cH:9][c:10](-[c:16]3[cH:17][cH:18][cH:19][cH:20][cH:21]3)[c:11](=[O:15])[n:12]1[CH2:13][CH2:14]2.[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:27]1)-[c:7]1[c:8]([CH2:22][N:23]([CH2:24][C:25]#[N:26])[CH:28]=[O:30])[cH:9][c:10](-[c:16]3[cH:17][cH:18][cH:19][cH:20][cH:21]3)[c:11](=[O:15])[n:12]1[CH2:13][CH2:14]2

参加物

反応物 3

HCID 8028Tetrahydrofuran

HCID 75269Acetic-formic anhydride

HCID 14770162[[(10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quinolizine-1-yl)methyl]amino]acetonitrile

生成物 1

HCID 19020395N-[(10-Chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quinolizine-1-yl)methyl]-N-(cyanomethyl)formamide

出典と根拠

ORDレコード: ord-813a09ce31da486f989634a63df4bade
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…