Hydrochloric Acid → Phthalylglycine aldehyde

HRID 216277

反応式

HRID 216277 の反応式
C(O[C:4]1([O:14]CC)[NH:8][C:7](=[O:9])[C:6]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:5]12)C.Cl.[C:18](OCC)(=[O:20])[CH3:19]>O1CCCC1>[O:14]=[C:4]1[C:5]2[C:6](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:7](=[O:9])[N:8]1[CH2:19][CH:18]=[O:20]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 66899166Phthalimide diethylacetal

生成物 1

HCID 76201Phthalylglycine aldehyde

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
75 °C

実験手順

To a solution of phthalimide diethylacetal (15 g) in tetrahydrofuran (THF) (30 mL) was added 10% aqueous HCl (18 mL). After heating at 75° C. for 5 hrs, the solution was allowed to cool to RT, and ethyl acetate (100 mL) was added. The solution was extracted with saturated sodium carbonate solution (100 mL), brine (100 mL), and the organic layer was separated and dried over magnesium sulfate (MgSO4). The solution was filtered and evaporated to provide 11.2 g of the titled compound.

後処理

  1. temperatureto cool to RT
  2. extractionThe solution was extracted with saturated sodium carbonate solution (100 mL), brine (100 mL)
  3. customthe organic layer was separated
  4. dry with materialdried over magnesium sulfate (MgSO4)
  5. filtrationThe solution was filtered
  6. customevaporated

出典と根拠

ORDレコード
ord-a990b9d9707c43e0b568c4def5e66c54
出典データセット
uspto-grants-2012_06
特許番号
US08193227B2

関連ノート

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