Chlorosulfonic acid → 5-fluoro-4-hydroxy-2-methylbenzenesulfonyl Chloride

HRID 216303ノート

反応式

HRID 216303 の反応式
[Cl:1][S:2]([OH:5])(=O)=[O:3].[F:6][C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][C:8]=1[OH:14]>ClCCl>[F:6][C:7]1[C:8]([OH:14])=[CH:9][C:10]([CH3:13])=[C:11]([S:2]([Cl:1])(=[O:5])=[O:3])[CH:12]=1

参加物

4

反応物 2

HCID 24638Chlorosulfonic acidHCID 182387Phenol, 2-fluoro-5-methyl-

生成物 1

HCID 847898185-fluoro-4-hydroxy-2-methylbenzenesulfonyl Chloride収率 7.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of chlorosulfonic acid (1.5 g, 13.3 mmol) dissolved in 10 mL of dichloromethane was added 2-fluoro-5-methylphenol (1.1 g, 8.86 mmol) dropwise. After 10 minutes, the reaction was quenched by adding to ice water. The reaction was extracted with dichloromethane, washed with brine, dried over MgSO4, filtered, and concentrated to give 150 mg (7.5%) of the title compound.

後処理

  1. customthe reaction was quenched
  2. additionby adding to ice water
  3. extractionThe reaction was extracted with dichloromethane
  4. washwashed with brine
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-2f5080c790b047c2ad93840e8b4185fd
出典データセット
uspto-grants-2012_06
特許番号
US08193227B2

反応ノート

読み込み中…