4-(5-fluoropyridin-2-yl)-N-methoxy-N-methylbenzamide → 1-(4-(5-Fluoropyridin-2-yl)phenyl)ethanone

HRID 216324ノート

反応式

HRID 216324 の反応式
[CH3:1][Mg]Br.[F:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:22]=[CH:21][C:14]([C:15](N(OC)C)=[O:16])=[CH:13][CH:12]=2)=[N:9][CH:10]=1>O1CCCC1>[F:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:22]=[CH:21][C:14]([C:15](=[O:16])[CH3:1])=[CH:13][CH:12]=2)=[N:9][CH:10]=1

参加物

4

反応物 2

HCID 866384894-(5-fluoropyridin-2-yl)-N-methoxy-N-methylbenzamideHCID 178418573HCID 178418573、化合物

生成物 1

HCID 591619481-(4-(5-Fluoropyridin-2-yl)phenyl)ethanone

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

Methylmagnesium bromide (3 M in tetrahydrofuran) (2.1 mL, 6.2 mmol) was added to a −78° C. solution of 4-(5-fluoropyridin-2-yl)-N-methoxy-N-methylbenzamide (800 mg, 3.1 mmol) in tetrahydrofuran (20 mL). After stirring at 0° C. for 30 min, the reaction mixture was quenched with methanol and saturated aqueous ammonium chloride. The organic layer was dried (magnesium sulfate) and concentrated in vacuo. Chromatography over silica eluting with 0-15% ethyl acetate/hexane afforded the title compound.

後処理

  1. customthe reaction mixture was quenched with methanol and saturated aqueous ammonium chloride
  2. dry with materialThe organic layer was dried (magnesium sulfate)
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-fb6eadfff345482abeb6415983a5f2e8
出典データセット
uspto-grants-2012_06
特許番号
US08193228B2

反応ノート

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