HCID 47149234、化合物 → 1-(6-(1H-pyrazol-1-yl)pyridin-3-yl)ethanone

HRID 216331ノート

反応式

HRID 216331 の反応式
[CH3:1][Mg]Br.CON(C)[C:7](=[O:19])[C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH:18]=[CH:17][CH:16]=[N:15]2)=[N:10][CH:9]=1>O1CCCC1>[N:14]1([C:11]2[N:10]=[CH:9][C:8]([C:7](=[O:19])[CH3:1])=[CH:13][CH:12]=2)[CH:18]=[CH:17][CH:16]=[N:15]1

参加物

4

反応物 2

HCID 47149234HCID 47149234、化合物HCID 178418573HCID 178418573、化合物

生成物 1

HCID 591619701-(6-(1H-pyrazol-1-yl)pyridin-3-yl)ethanone

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Methylmagnesium bromide (3 M in tetrahydrofuran) (3.16 mL, 9.5 mmol) was added to a −78° C. solution of N-methoxy-N-methyl-6-(1H-pyrazol-1-yl)nicotinamide (2.0 g, 8.6 mmol) in tetrahydrofuran (10 mL). After stirring at ambient temperature overnight, the reaction mixture was quenched with brine and extracted with ethyl acetate. The combined organic extracts were dried (magnesium sulfate) and concentrated in vacuo to afford the title compound.

後処理

  1. customthe reaction mixture was quenched with brine
  2. extractionextracted with ethyl acetate
  3. dry with materialThe combined organic extracts were dried (magnesium sulfate)
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-5d0799ced85c4737a9e4e275e5ff81a5
出典データセット
uspto-grants-2012_06
特許番号
US08193228B2

反応ノート

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