Potassium Hydroxide → HCID 12822283、化合物

反応式

[C:1]1([C:7]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([CH:10]2[CH2:13][N:12]([CH:14](C3C=CC=CC=3)C)[CH2:11]2)[C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+]>[Pd].C(O)C>[C:1]1([C:7]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([CH:10]2[CH2:13][N:12]([CH3:14])[CH2:11]2)[C:8]#[N:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

実験手順

A solution of 800 ml. of ethanol and 59 g. (0.13 mole) of α,α-diphenyl-α-[1-(1-phenylethyl)-3-azetidinyl]acetonitrile methobromide was treated with 7.12 g. (0.13 mole) of potassium hydroxide and 0.25 g. of 10% palladium on carbon. The mixture was shaken under initial hydrogen pressure of 45 p.s.i. at ambient temperature for 24 hours. The mixture was filtered and the filtrate concentrated. The residue was crystallized from isooctane to give 21.7 g. (64%) of product melting 112°-115° C.