2-Aminopyridine → HCID 22752766、化合物
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[Br:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH2:16][Cl:17]>C1(C)C(C)=CC=CC=1>[Cl-:17].[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N+:3]=1[CH2:16][O:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[Br:8]参加物
4
実験手順
To a solution of 7.1 g of 2-aminopyridine in 35 ml of xylene is added, dropwise, a solution of 11.1 g of o-bromo-α-chloroanisole in 45 ml of xylene. The mixture is warmed at 50° for 5 minutes and allowed to stir for 40 hours at room temperature. The solid is filtered and dried to give about 16.0 g of the product. This is recrystallized from 2-propanol to give about 14.0 g of the title product, mp 171°-173°.
後処理
- temperatureThe mixture is warmed at 50° for 5 minutes
- filtrationThe solid is filtered
- customdried
出典と根拠
- ORDレコード
- ord-e8aa2e8a437c4838a852ea9ed9cdee44
- 出典データセット
- uspto-grants-1979_01
- 特許番号
- US04134975
反応ノート
読み込み中…