Water → 3,5-dimethyl-N-phenyl-1H-pyrazole-4-carboxamide

HRID 2163520ノート

反応式

HRID 2163520 の反応式
[C:1]([CH:4]([C:14](=O)[CH3:15])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:6])(=O)[CH3:2].O.[NH2:18][NH2:19].O>C(O)(=O)C>[CH3:2][C:1]1[C:4]([C:5]([NH:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:6])=[C:14]([CH3:15])[NH:19][N:18]=1

参加物

5

反応物 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 22033802HCID 22033802、化合物

生成物 1

HCID 107038853,5-dimethyl-N-phenyl-1H-pyrazole-4-carboxamide収率 88%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

The foregoing diacetyl acetanilide (2.2 g) in glacial acetic acid (30 ml) was treated with hydrazine hydrate (1.5 g) and the mixture boiled under reflux for 30 min. The mixture was then poured into water and the product collected and crystallised from ethanol. 3,5-dimethyl-N-phenyl-4-pyrazolecarboxamide (1.9 g, 86%) was obtained as colourless plates, m.p. 244-5° C (Found: C, 66.8 H, 6.0 N, 19.3 C12H13N3O requires C, 66.9; H, 6.1; N, 19.5%).

後処理

  1. temperatureunder reflux for 30 min
  2. customthe product collected
  3. customcrystallised from ethanol

出典と根拠

ORDレコード
ord-fafb41a2053543a0be3cc30d3ef182a7
出典データセット
uspto-grants-1979_01
特許番号
US04134987

反応ノート

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