Sodium Hydroxide → N-[(4-Chlorophenyl)(phenyl)methyl]-4,5-dihydro-1H-imidazol-2-amine

HRID 2163673ノート

反応式

HRID 2163673 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH2:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.I.CS[C:19]1[NH:20][CH2:21][CH2:22][N:23]=1.[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([N:15]=[C:19]2[NH:23][CH2:22][CH2:21][NH:20]2)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 409810(4-Chlorophenyl)(phenyl)methanamineHCID 122212281H-Imidazole, 4,5-dihydro-2-(methylthio)-, hydriodide (1:1)

生成物 1

HCID 178478141N-[(4-Chlorophenyl)(phenyl)methyl]-4,5-dihydro-1H-imidazol-2-amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 3.37 g of α-(p-chlorophenyl)benzylamine and 4.54 g of 2-methylmercapto-2-imidazoline-hydroiodide was heated at 150°-160° C. for 20 minutes. After cooling, the reaction mixture was dissolved in methanol and the solution rendered basic with sodium hydroxide to give 2-(α-(p-chlorophenyl)benzyl)iminoimidazolidine having a melting point of 187°-189° C.

後処理

  1. temperaturewas heated at 150°-160° C. for 20 minutes
  2. temperatureAfter cooling

出典と根拠

ORDレコード
ord-a3241b119fbd48bcbe79420568306ca1
出典データセット
uspto-grants-1979_01
特許番号
US04136188

反応ノート

読み込み中…