4-tert-Butylbenzenesulfonamide → N-[4-(hexadecylamino)benzoyl]-4-t-butylbenzenesulfonamide

HRID 2163762

反応式

HRID 2163762 の反応式
Cl.[CH2:2]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[C:28]([C:32]1[CH:37]=[CH:36][C:35]([S:38]([NH2:41])(=[O:40])=[O:39])=[CH:34][CH:33]=1)([CH3:31])([CH3:30])[CH3:29]>N1C=CC=CC=1>[CH2:2]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:41][S:38]([C:35]2[CH:36]=[CH:37][C:32]([C:28]([CH3:31])([CH3:30])[CH3:29])=[CH:33][CH:34]=2)(=[O:39])=[O:40])=[O:24])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

参加物

4

反応物 2

HCID 2228724-tert-ButylbenzenesulfonamideHCID 132553224-Hexadecylaminobenzoyl chloride hydrochloride

生成物 1

HCID 20437349N-[4-(hexadecylamino)benzoyl]-4-t-butylbenzenesulfonamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A solution of 21.1 g. of 4-(hexadecylamino)benzoyl chloride hydrochloride and 10.8 g. of p-tert-butylbenzenesulfonamide in 250 ml. of pyridine was stirred under reflux for 2 hours and evaporated. The residue was partitioned between 1N hydrochloric acid and CH2Cl2 and the organic layer was separated, washed with water, dried (MgSO4), and evaporated. Crystallization of the residual glass from CH2Cl2 hexane afforded a white solid, melting point 173°-176° C.

後処理

  1. temperatureunder reflux for 2 hours
  2. customevaporated
  3. customThe residue was partitioned between 1N hydrochloric acid and CH2Cl2
  4. customthe organic layer was separated
  5. washwashed with water
  6. dry with materialdried (MgSO4)
  7. customevaporated
  8. customCrystallization of the residual glass from CH2Cl2 hexane
  9. customafforded a white solid, melting point 173°-176° C.

出典と根拠

ORDレコード
ord-f5471b222d6e40188886a9c207516c5f
出典データセット
uspto-grants-1979_01
特許番号
US04136256

関連ノート

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