Hydrochloric Acid → HCID 178442243、化合物
反応式
Cl.[CH3:2][C:3]([CH3:37])([CH3:36])[CH2:4][C:5]1[N:6]=[C:7]([CH:16]([OH:35])[C:17]2([C:23]3[CH:28]=[CH:27][C:26]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=4)=[CH:25][CH:24]=3)[S:22][CH2:21][CH2:20][CH2:19][S:18]2)[N:8](S(N(C)C)(=O)=O)[CH:9]=1>O1CCCC1>[CH3:2][C:3]([CH3:37])([CH3:36])[CH2:4][C:5]1[N:6]=[C:7]([CH:16]([C:17]2([C:23]3[CH:28]=[CH:27][C:26]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=4)=[CH:25][CH:24]=3)[S:18][CH2:19][CH2:20][CH2:21][S:22]2)[OH:35])[NH:8][CH:9]=1参加物
4
反応条件
- 温度
- 70 °C
実験手順
Step C, 1.5 N Hydrochloric acid (1 mL) was added to a solution of 4-(2,2-dimethylpropyl)-2-{hydroxy[2-(4-pyridin-2-ylphenyl)-1,3-dithian-2-yl]methyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide in tetrahydrofuran (1 mL). After heating in a sealed tube at 70° C. for a few minutes until no further reaction (LCMS), the reaction mixture was cooled to 0° C., quenched with 10% aqueous sodium hydroxide and extracted with ethyl acetate. The combined organic extracts were dried (magnesium sulfate) and concentrated in vacuo. Preparatory plate chromatography eluting with 10% methanol/ethyl aceate afforded the title compound. LCMS: 440 (M+H).