Benzoyl chloride → N'-tert-butylbenzohydrazide

HRID 21641

反応式

HRID 21641 の反応式
Cl.[C:2]([NH:6][NH2:7])([CH3:5])([CH3:4])[CH3:3].[OH-].[Na+].[C:10](Cl)(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1(C)C=CC=CC=1>[C:2]([NH:6][NH:7][C:10](=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([CH3:5])([CH3:4])[CH3:3]

参加物

5

反応物 3

HCID 7412Benzoyl chlorideHCID 14798Sodium Hydroxide2 回HCID 81889tert-Butylhydrazine monohydrochloride

生成物 1

HCID 299436N'-tert-butylbenzohydrazide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

反応条件

温度
5 °C

実験手順

To a stirred suspension of t-butylhydrazine hydrochloride (1 g, 0.008M) in toluene (30 ml) at room temperature was added dropwise a 50% aqueous solution of sodium hydroxide (0.64 g, 0.008M). After 15 minutes, the reaction mixture was cooled to 5° C. and a solution of benzoyl chloride (1.12 g, 0.008M) in toluene (5 ml) and a solution of aqueous 50% sodium hydroxide (0.64 g, 0.008M) were added dropwise simultaneously from separate addition funnels while maintaining the temperature at or below 10° C. Following the addition, the reaction mixture was warmed to room temperature and stirred for 1 hour. The reaction was diluted with hexane and the solid N'-t-butyl-N-benzoylhydrazine was isolated by filtration.

後処理

  1. customfrom separate
  2. additionaddition funnels
  3. temperaturewhile maintaining the temperature at or below 10° C
  4. additionthe addition
  5. temperaturethe reaction mixture was warmed to room temperature
  6. additionThe reaction was diluted with hexane

出典と根拠

ORDレコード
ord-c622e25d2a7044dd93f3202775f54fc5
出典データセット
uspto-grants-1995_06
特許番号
US05424333

関連ノート

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